Your browser doesn't support javascript.
loading
Replicating centromeric chromatin: spatial and temporal control of CENP-A assembly.
Nechemia-Arbely, Yael; Fachinetti, Daniele; Cleveland, Don W.
Afiliação
  • Nechemia-Arbely Y; Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA.
Exp Cell Res ; 318(12): 1353-60, 2012 Jul 15.
Article em En | MEDLINE | ID: mdl-22561213
ABSTRACT
The centromere is the fundamental unit for insuring chromosome inheritance. This complex region has a distinct type of chromatin in which histone H3 is replaced by a structurally different homologue identified in humans as CENP-A. In metazoans, specific DNA sequences are neither required nor sufficient for centromere identity. Rather, an epigenetic mark comprised of CENP-A containing chromatin is thought to be the major determinant of centromere identity. In this view, CENP-A deposition and chromatin assembly are fundamental processes for the maintenance of centromeric identity across mitotic and meiotic divisions. Several lines of evidence support CENP-A deposition in metazoans occurring at only one time in the cell cycle. Such cell cycle-dependent loading of CENP-A is found in divergent species from human to fission yeast, albeit with differences in the cell cycle point at which CENP-A is assembled. Cell cycle dependent CENP-A deposition requires multiple assembly factors for its deposition and maintenance. This review discusses the regulation of new CENP-A deposition and its relevance to centromere identity and inheritance.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoantígenos / Cromatina / Proteínas Cromossômicas não Histona / Centrômero / Replicação do DNA / Multimerização Proteica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoantígenos / Cromatina / Proteínas Cromossômicas não Histona / Centrômero / Replicação do DNA / Multimerização Proteica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2012 Tipo de documento: Article