Synthesis of purine homo-N-nucleosides modified with coumarins as free radicals scavengers.
J Enzyme Inhib Med Chem
; 28(4): 765-75, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-22591318
ABSTRACT
Cross metathesis (CM) of 9-butenylpurines with 4-butenyloxycoumarin in the presence of Grubbs 2nd generation catalyst under MW irradiation resulted to conjugated compounds containing homo-N-nucleosides and coumarins. Analogous derivatives received by the CM reaction of 9-butenyl-6-piperidinylpurine with 6- or 7-butenyloxycoumarins, allyloxycoumarins or coumarinyl acrylate. These compounds were tested in vitro for their antioxidant activity and they present significant scavenging activity. The presence of a pentenyloxy moiety, the attachment position on coumarin ring as well as a purine homo-N-nucleoside group are considered as important structural features.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Purinas
/
Sequestradores de Radicais Livres
/
Cumarínicos
/
Nucleosídeos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article