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Effectiveness of vaccination and antibiotics to control Coxiella burnetii shedding around calving in dairy cows.
Taurel, Anne-Frieda; Guatteo, Raphaël; Joly, Alain; Beaudeau, François.
Afiliação
  • Taurel AF; ONIRIS, Nantes F-44307, France. anne-frieda.taurel@nantes-oniris.fr
Vet Microbiol ; 159(3-4): 432-7, 2012 Oct 12.
Article em En | MEDLINE | ID: mdl-22595136
Effectiveness of phase 1 vaccine, combined or not with tetracycline, to control Coxiella burnetii vaginal shedding at calving in cows was assessed through a 13 months study in 22 Q fever clinically affected commercial dairy herds. Four medical strategies implemented at herd level but randomly assigned to cows (vaccination, vaccination and tetracycline, tetracycline, nothing) were compared. There was no significant interaction effect between vaccination and antibiotherapy. Tetracycline used once at drying off was associated with a lower risk of being detected shedder at calving (OR=0.40, CI 95% [0.21-0.75]), but had no significant effect on the bacterial load shed. Vaccination did not significantly prevent shedding but was significantly (OR=0.15, CI 95% [0.03-0.85]) associated with lower bacterial load shed. Thus, vaccination using a phase 1 vaccine and antibiotherapy using tetracycline is associated with a decrease in shedding in dairy cows and could contribute to reduce the bacterial load generated in the environment. To the best of our knowledge, this is the first study providing useful information for evidenced-based and rational use of medical strategy combining antibiotic and vaccination in infected dairy cattle herds.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Febre Q / Tetraciclina / Vacinas Bacterianas / Doenças dos Bovinos / Derrame de Bactérias / Antibacterianos Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Febre Q / Tetraciclina / Vacinas Bacterianas / Doenças dos Bovinos / Derrame de Bactérias / Antibacterianos Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2012 Tipo de documento: Article