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Vertebral body corner oedema vs gadolinium enhancement as biomarkers of active spinal inflammation in ankylosing spondylitis.
Wang, Y-X J; Griffith, J F; Deng, M; Li, T K; Tam, L-S; Lee, V W Y; Lee, K K C; Li, E K.
Afiliação
  • Wang YX; Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital,Shatin, Hong Kong, China. yixiang_wang@cuhk.edu.hk
Br J Radiol ; 85(1017): e702-8, 2012 Sep.
Article em En | MEDLINE | ID: mdl-22595499
OBJECTIVE: To investigate the relative performance of T(2) weighted short tau inversion-recovery (STIR) and fat-suppressed T(1) weighted gadolinium contrast-enhanced sequences in depicting active inflammatory lesions in ankylosing spondylitis (AS). METHODS: Whole-spine MRI was performed on 32 patients with AS, who participated in a clinical trial of infliximab treatment, by STIR and contrast-enhanced sequences at baseline and after 30 weeks. The AS spine MRI-activity (ASspiMRI-a) scoring method was used. The images from these two imaging techniques were evaluated separately by two independent readers. RESULTS: For the pre-treatment lesion status, the intraclass correlation coefficients comparing STIR readings and contrast-enhanced readings were 0.69±0.23 for Reader 1 and 0.65±0.21 for Reader 2. At baseline, the mean ASspiMRI-a score was 15.4% and 17.7% higher for contrast-enhanced images than for STIR images for Reader 1 and Reader 2, respectively. After infliximab treatment, Reader 1 rated an ASspiMRI-a score reduction of 50.8±33.6% and 25.3±35.3% for STIR images and contrast-enhanced images, respectively, whereas Reader 2 rated an ASspiMRI-a score reduction of 42.4±50.4% and 32.9±35.6% for STIR images and contrast-enhanced images, respectively. CONCLUSION: While both contrast-enhanced and STIR sequences showed sensitivity to change over a short period of time after infliximab treatment, these two sequences may reflect different disease mechanisms.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / Coluna Vertebral / Espondilite Anquilosante / Imageamento por Ressonância Magnética / Aumento da Imagem / Edema / Imagem Corporal Total / Meglumina Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / Coluna Vertebral / Espondilite Anquilosante / Imageamento por Ressonância Magnética / Aumento da Imagem / Edema / Imagem Corporal Total / Meglumina Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2012 Tipo de documento: Article