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Older age and capacity of colony forming unit in autologous peripheral derived hematopoietic cells.
Civriz Bozdag, S; Bay, M; Ayyildiz, E; Topcuoglu, P; Ilhan, O.
Afiliação
  • Civriz Bozdag S; Department of Hematology, Ankara University School of Medicine, Ankara, Turkey. scivriz@hotmail.com
Transfus Apher Sci ; 47(1): 113-6, 2012 Aug.
Article em En | MEDLINE | ID: mdl-22633541
BACKGROUND: Aging decreases bone marrow cellularity and alters the frequencies of stem cells. Aged hematopoietic stem cells can differ from their younger counterparts in functional capacity. STUDY DESIGN AND METHODS: We aimed to evaluate the relation between the age and the ability of colony forming capacity of peripheral blood-derived hematopoietic cell products collected for autologous stem cell transplantation (AHSCT). RESULTS: Elderly patients could be mobilized with lower total collected CD34+ cells. Colony forming capacity did not differ between young and old patients. CONCLUSION: This results can be translated into clinic as higher numbers of AHSCT candidates over age 60.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Células-Tronco Hematopoéticas / Mobilização de Células-Tronco Hematopoéticas / Transplante de Células-Tronco de Sangue Periférico Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Células-Tronco Hematopoéticas / Mobilização de Células-Tronco Hematopoéticas / Transplante de Células-Tronco de Sangue Periférico Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2012 Tipo de documento: Article