Valvular heart diseases in the developing world: developmental biology takes center stage.
J Heart Valve Dis
; 21(2): 234-40, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-22645860
ABSTRACT
Heart valve disease is a significant and increasing global problem of which, in the developing world, the primary sufferers are the children and young adults regarded as the critical 'engine' of future economic growth. Yet, up to 10 times the current number of known sufferers remain undiagnosed in these countries. Among the most prevalent and neglected diseases are rheumatic heart disease and endomyocardial fibrosis. The etiologies of these diseases can be described in part as a dysregulation or reactivation of developmental biology pathways. Consequently, connecting mechanisms of valvulogenesis and disease etiology may represent an excellent strategy to identify therapeutic targets. These local diseases require local solutions tailored to local resources; therefore, collaboration with experienced research groups should be encouraged as a way of accelerating the creation of relevant knowledge, and its clinical translation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cardiopatia Reumática
/
Países em Desenvolvimento
/
Fibrose Endomiocárdica
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article