Enhanced lung colonization and tumorigenicity of fused cells isolated from primary MCA tumors.
Cancer Lett
; 55(2): 109-14, 1990 Dec 03.
Article
em En
| MEDLINE
| ID: mdl-2265408
ABSTRACT
Cells derived from cell-cell fusion events were clonally isolated from primary methylcholanthrene (MCA)-induced tumors in allophenic mice. Compared with non-fused cells isolated from the same cultures, the fused cells had markedly greater experimental metastasizing (lung colonizing) activity, but only slightly greater tumorigenicity and the same cloning efficiency in soft agar. Cell-cell fusion may thus contribute to the generation of tumor heterogeneity that underlies the process of tumor progression.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pulmonares
/
Metástase Neoplásica
/
Neoplasias Experimentais
Limite:
Animals
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article