Questions over high frequency of mutant PfATP6 haplotypes in traveller isolates.
Malar J
; 11: 186, 2012 Jun 08.
Article
em En
| MEDLINE
| ID: mdl-22681876
ABSTRACT
A recent paper in Malaria Journal suggests that a high proportion of Plasmodium falciparum isolates found in travellers returning from a range of African countries carry the PfATP6 A623E S769N haplotype, and that this genotype is associated with artemether resistance. Such a finding would represent a substantial departure from the extensive literature reporting these individual mutations to be very rare, with the double mutation never documented. The number of isolates screened to obtain these double mutants is unstated, but highly relevant, not least because selection of isolates could have introduced significant confounders, such as timing of in vitro testing. An additional concern relates to the location of sequencing primers used to assess these positions. In the absence of clear information on these fundamental questions it would be appropriate to treat the findings with caution.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Resistência a Medicamentos
/
Malária Falciparum
/
ATPases Transportadoras de Cálcio
/
Proteínas Associadas à Resistência a Múltiplos Medicamentos
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Artemisininas
/
Antimaláricos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article