Antibacterial and antifungal activity of lawsone and novel naphthoquinone derivatives.
Med Mal Infect
; 42(6): 270-5, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22682997
ABSTRACT
INTRODUCTION:
Naphthoquinone derivatives are under investigation as potential therapeutic agents. The antibacterial and antifungal activity of lawsone and of some novel naphthoquinone derivatives was assessed in vitro.METHODS:
The antimicrobial activity was determined using diffusion disk and the broth microdilution methods against seven bacteria and three Candida species, according to recommendations of the Clinical and Laboratory Standards Institute.RESULTS:
Two compounds (P05 et P06) presented a good antibacterial effectiveness against two gram-positive bacteria. No antifungal potency was observed against the three Candida albicans strains used in the test.CONCLUSION:
Our results prove that the introduction of substituents on ketone function position 4 decreased the antimicrobial properties of the synthetized compounds.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Naftoquinonas
/
Antibacterianos
/
Antifúngicos
Tipo de estudo:
Guideline
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article