Synthesis and biological evaluation of thiophene derivatives as acetylcholinesterase inhibitors.
Molecules
; 17(6): 7217-31, 2012 Jun 12.
Article
em En
| MEDLINE
| ID: mdl-22692245
ABSTRACT
A series of new thiophene derivatives has been synthesized using the Gewald protocol. The acetylcholinesterase inhibition activity was assayed according to Ellman's method using donepezil as reference. Some of the compounds were found to be more potent inhibitors than the reference. 2-(2-(4-(4-Methoxyphenyl)piperazin-1-yl)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (IIId) showed 60% inhibition, compared to only 40% inhibition by donepezil.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiofenos
/
Inibidores da Colinesterase
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article