Hepatitis B virus infection increases the risk of cholangiocarcinoma: a meta-analysis and systematic review.
J Gastroenterol Hepatol
; 27(10): 1561-8, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22694354
ABSTRACT
BACKGROUND AND AIM:
A number of studies have shown that hepatitis virus infections may be associated with cholangiocarcinoma (CC). However, the relationship between hepatitis B virus (HBV) infection and CC, especially intrahepatic cholangiocarcinoma (ICC), is still controversial.METHODS:
Relevant studies were identified by searching PUBMED, EMBASE and Web of Science Datebases up to September 2011. Pooled risk estimates were calculated using a random-effects model. Potential sources of heterogeneity were performed by subgroup analyses. A total of 18 papers were included in this meta-analysis.RESULTS:
The pooled risk estimate of all studies showed a statistically significant increased risk of CC among individuals with HBV infection (rate ratio [RR] 2.66; 95% confidence interval [CI] 1.97, 3.60). Compared with those without HBV infection, persons with HBV infection had an increased risk of intra-CC (ICC) (RR 3.42; 95% CI 2.46, 43.74), extrahepatic CC (OR 1.46; 95% CI 0.98, 2.17), and CC (OR 2.03; 95% CI 1.15, 3.56). In a subgroup analysis of HBV infection and risk of ICC, the pooled risk estimate of studies in Asians (RR 3.63; 95% CI 2.56, 5.13) was higher than that in non-Asians (RR 1.93; 95% CI 0.78, 4.76). A Begg funnel plot and Egger test revealed no evidence for publication bias.CONCLUSIONS:
This meta-analysis shows that HBV is associated with increased risk of CC, especially for ICC. Further investigation is needed to focus on the mechanism by which HBV may be involved in the pathogenesis of CC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias dos Ductos Biliares
/
Ductos Biliares Intra-Hepáticos
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Colangiocarcinoma
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Hepatite B
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Neoplasias Hepáticas
Tipo de estudo:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Adult
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Aged
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Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article