The clinical diagnostic significance of cerebrospinal fluid D-lactate for bacterial meningitis.
Clin Chim Acta
; 413(19-20): 1512-5, 2012 Oct 09.
Article
em En
| MEDLINE
| ID: mdl-22713513
ABSTRACT
BACKGROUND:
To study the clinical and laboratory significance of Dlactate in the diagnosis of bacterial meningitis (BM).METHODS:
The levels of Dlactate, Llactate, IL-6, IL-8, and other biochemical markers were determined in 83 CSF samples from different types of meningitis and the controls.RESULTS:
The CSF values of Dlactate, Llactate, IL-6, IL-8, erythrocytes, leukocytes, and protein were higher in patients with BM than those in the controls and patients with viral meningitis. The levels of Dlactate, Llactate, IL-6, and erythrocytes in the BM group were higher than those in the tuberculous meningitis group. At the cutoff 12.8 µmol/l, Dlactate showed the diagnostic sensitivity of 94.7%. Dlactate gave the area under the curve (AUC) 0.905, which was higher than those of other markers. Using multiple marker detection, the AUC reached 0.956, which was the highest among all the parameters. Pearson correlation analysis revealed that Dlactate was positively correlated to IL-6 and Llactate (r=0.727, 0.789 and P=0.000, 0.000, respectively).CONCLUSIONS:
THE CSF concentrations of Dlactate are significantly increased in the presence of BM. Measurement of Dlactate provides a rapid diagnosis and differential diagnosis for BM. Combination of Dlactate with other biochemical markers improves the specificity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Meningites Bacterianas
/
Ácido Láctico
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Meningite Viral
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adolescent
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Adult
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Aged
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Child
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Child, preschool
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article