Mild synthetic approach to novel indole-1-carbinols and preliminary evaluation of their cytotoxicity in hepatocarcinoma cells.
Arch Pharm (Weinheim)
; 345(3): 195-202, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-22715502
ABSTRACT
A mild and versatile method for the synthesis of some novel indole-1-carbinols has been developed via one-pot reaction of indoles and paraformaldehyde in the presence of an excess of CaO, MgO, ZnO or TiO(2). The solvent-free reaction provided all the indole derivatives in moderate to good yields and short reaction times. Moreover, the effect of some selected indole-1-carbinols on cell proliferation of the hepatoma cell line FaO was evaluated.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Metanol
/
Indóis
/
Antineoplásicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article