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[Characteristic of microglial activation of hippocampus in experimental epileptic rats].
Sun, Hong; Wu, Hai-qin; Zhang, Gui-lian; Zhan, Shu-qin; Zhang, Ru; Wang, Hu-qing.
Afiliação
  • Sun H; Department of Neurology, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, China. sunhongxjt@yahoo.cn
Zhejiang Da Xue Xue Bao Yi Xue Ban ; 41(3): 310-4, 2012 05.
Article em Zh | MEDLINE | ID: mdl-22723167
OBJECTIVE: To investigate the characteristics of microglial activation of hippocampus in experimental epileptic rats. METHODS: Morphological changes and proliferation of OX-42 positive cells were compared at different time points after status of epilepticus (SE) in lithium-pilocarpine induced epileptic rats. RESULTS: OX-42 positive cells were activated after SE, which increased to a peak at 3-7 d and in a relatively stable state at 7-14 d; then gradually decreased after 14d and returned to slightly higher level than previously at 21 d. CONCLUSION: Inflammatory injury, microglial activation and cell proliferation are closely related after seizures, microglial activation may be an important mechanism in the inflammatory injury of epilepsy.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estado Epiléptico / Microglia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: Zh Ano de publicação: 2012 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estado Epiléptico / Microglia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: Zh Ano de publicação: 2012 Tipo de documento: Article