Design, synthesis, and photochemical validation of peptide linchpins containing the S,S-tetrazine phototrigger.
Org Lett
; 14(13): 3518-21, 2012 Jul 06.
Article
em En
| MEDLINE
| ID: mdl-22731895
ABSTRACT
The design, solid-phase synthesis, and photochemical validation of diverse peptide linchpins, containing the S,S-tetrazine phototrigger, have been achieved. Steady state irradiation or femtosecond laser pulses confirm their rapid photofragmentation. Attachment of peptides to the C- and N-termini will provide access to diverse constrained peptide constructs that hold the promise of providing information about early peptide/protein conformational dynamics upon photochemical release.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Tetrazóis
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article