Spatio-temporal expression study of phosphorylated 70-kDa ribosomal S6 kinase (p70S6k) in mesial temporal lobe epilepsy.
Chin Med Sci J
; 27(1): 7-10, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-22734207
ABSTRACT
OBJECTIVE:
To determine the spatio-temporal expression of p70S6k activation in hippocampus in mesial temporal lobe epilepsy.METHODS:
Temporal lobe epilepsy model was established by stereotaxically unilateral and intrahippocampal injection of kainite acid (KA) in adult male C57BL/6 mice. Latent and chronic epileptogenesis were represented by mice 5 days after KA injection (n = 5) and mice 5 weeks after KA injection (n = 8), respectively. Control mice (n = 5) were injected with saline. Immunohistochemical assays were performed on brain sections of the mice.RESULTS:
Hippocampus both ipsilateral and contralateral to the KA injection displayed significantly up-regulated pS6 immunoreactivity in dispersed granule cells in 5-day and 5-week model mice.CONCLUSION:
The activation of p70S6k is mainly located in the dentate gyrus in KA-induced mouse model of temporal lobe epilepsy, indicating that the activation may be related with the disperse degree and hypertrophy of granule cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases S6 Ribossômicas 70-kDa
/
Epilepsia do Lobo Temporal
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article