Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: synthesis and pharmacological evaluation.
Bioorg Med Chem Lett
; 22(15): 5046-50, 2012 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-22749280
ABSTRACT
The synthesis and evaluation of antiplasmodial activity of benzothiazole, benzimidazole, benzoxazole and pyridine analogues of amodiaquine is hereby reported. Benzothiazole and benzoxazole analogues with a protonatable tertiary nitrogen atom possessed excellent activity against the W2 and K1 chloroquine resistant strains of Plasmodium falciparum, with IC(50)s ranging from 7 to 22 nM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Amodiaquina
/
Antimaláricos
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article