Automated solid-phase synthesis of hyaluronan oligosaccharides.
Org Lett
; 14(14): 3776-9, 2012 Jul 20.
Article
em En
| MEDLINE
| ID: mdl-22780913
ABSTRACT
Well-defined fragments of hyaluronic acid (HA) have been obtained through a fully automated solid-phase oligosaccharide synthesis. Disaccharide building blocks, featuring a disarmed glucuronic acid donor moiety and a di-tert-butylsilylidene-protected glucosamine part, were used in the rapid and efficient assembly of HA fragments up to the pentadecamer level, equipped with a conjugation-ready anomeric allyl function.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligossacarídeos
/
Dissacarídeos
/
Glucosamina
/
Ácido Hialurônico
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article