[Neuromyelitis optica in children. Two case reports]. / Neuromyélite optique chez l'enfant. À propos de deux cas.
Arch Pediatr
; 19(8): 827-31, 2012 Aug.
Article
em Fr
| MEDLINE
| ID: mdl-22789744
ABSTRACT
Devic neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system associating acute transverse myelitis and optic neuritis. This is a different disease from multiple sclerosis for which the presence of the NMO antibody directed against aquaporin 4 is a specific marker. Brain damage on MRI does not exclude the diagnosis; the location is superposable in the brain zones rich in aquaporin 4 channels. We report 2 cases of NMO with anti-aquaporin 4. One patient was not symptomatic of brain damage. In this patient, the affinity of anti-NMO for aquaporin 4, studied by flow cytometry, was particularly high. Both patients were treated with immunosuppressive agents (rituximab) due to the failure of or dependence on high-dose corticosteroids.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neuromielite Óptica
Limite:
Adolescent
/
Female
/
Humans
Idioma:
Fr
Ano de publicação:
2012
Tipo de documento:
Article