Regulatory element copy number differences shape primate expression profiles.
Proc Natl Acad Sci U S A
; 109(31): 12656-61, 2012 Jul 31.
Article
em En
| MEDLINE
| ID: mdl-22797897
ABSTRACT
Gene expression differences are shaped by selective pressures and contribute to phenotypic differences between species. We identified 964 copy number differences (CNDs) of conserved sequences across three primate species and examined their potential effects on gene expression profiles. Samples with copy number different genes had significantly different expression than samples with neutral copy number. Genes encoding regulatory molecules differed in copy number and were associated with significant expression differences. Additionally, we identified 127 CNDs that were processed pseudogenes and some of which were expressed. Furthermore, there were copy number-different regulatory regions such as ultraconserved elements and long intergenic noncoding RNAs with the potential to affect expression. We postulate that CNDs of these conserved sequences fine-tune developmental pathways by altering the levels of RNA.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pseudogenes
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Regulação da Expressão Gênica
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Dosagem de Genes
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DNA Intergênico
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RNA não Traduzido
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Elementos Reguladores de Transcrição
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article