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High diagnostic value of synovial biopsy in periprosthetic joint infection of the hip.
Fink, Bernd; Gebhard, Alexander; Fuerst, Martin; Berger, Irina; Schäfer, Peter.
Afiliação
  • Fink B; Department of Joint Replacement, General and Rheumatic Orthopaedics, Orthopaedic Clinic Markgröningen, Kurt-Lindemann-Weg 10, Markgröningen 71706, Germany. b.fink@okm.de
Clin Orthop Relat Res ; 471(3): 956-64, 2013 Mar.
Article em En | MEDLINE | ID: mdl-22806261
ABSTRACT

BACKGROUND:

The role of the synovial biopsy in the preoperative diagnosis of a periprosthetic joint infection (PJI) of the hip has not been clearly defined. QUESTIONS/

PURPOSES:

We asked whether the value of a biopsy for a PJI is greater than that of aspiration and C-reactive protein (CRP).

METHODS:

Before revision in 100 hip endoprostheses, we obtained CRP values, aspirated the joint, and obtained five synovial biopsy samples for bacteriologic analysis and five for histologic analysis. Microbiologic and histologic analyses of the periprosthetic tissue during revision surgery were used to verify the results of the preoperative diagnostic methods. The minimum followup was 24 months (median 32; range, 24-47 months).

RESULTS:

Forty-five of the 100 prostheses were identified as infected. The biopsy, with a combination of the bacteriologic and histologic examinations, showed the greatest diagnostic value of all the diagnostic procedures and led to a sensitivity of 82% (95% CI, ± 11%), specificity of 98% (95% CI, ± 4%), positive predictive value of 97% (95% CI, ± 5%), negative predictive value of 87% (95% CI, ± 8.3%), and accuracy of 91%.

CONCLUSIONS:

The biopsy technique has a greater value than aspiration and CRP in the diagnosis of PJI of the hip (Masri et al. J Arthroplasty 2272-78, 2007). In patients with a negative aspirate, but increased CRP or clinical signs of infection, we regard biopsy to be preferable to just repeating the aspiration. LEVEL OF EVIDENCE Level II prognostic study. See Guidelines for Authors for a complete description of levels of evidence.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biópsia / Infecções Relacionadas à Prótese / Artroplastia de Quadril / Sinovectomia / Articulação do Quadril / Prótese de Quadril Tipo de estudo: Diagnostic_studies / Evaluation_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biópsia / Infecções Relacionadas à Prótese / Artroplastia de Quadril / Sinovectomia / Articulação do Quadril / Prótese de Quadril Tipo de estudo: Diagnostic_studies / Evaluation_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2013 Tipo de documento: Article