Abnormal second-trimester serum analytes are more predictive of preterm preeclampsia.
Am J Obstet Gynecol
; 207(3): 228.e1-7, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-22818876
ABSTRACT
OBJECTIVE:
We sought to determine the association of abnormal second-trimester serum analytes with early preterm preeclampsia. STUDYDESIGN:
We conducted a retrospective study of 7767 subjects undergoing second-trimester serum aneuploidy screening. Values of maternal serum α-fetoprotein (AFP), ß-human chorionic gonadotropin (hCG), and inhibin (INH) were calculated as multiples of the median (MoM) and evaluated by gestational age at delivery and occurrence of preeclampsia.RESULTS:
Of 459 (6.5%) cases of preeclampsia, 65 (14%) delivered <34 weeks and 394 (86%) delivered >34 weeks. Elevated AFP, hCG, and INH >2 MoM were associated with preeclampsia, and the odds ratio was higher for the development of preeclampsia <34 weeks than >34 weeks (odds ratio, 8.04 vs 2.91 for AFP, 3.6 vs 2 for hCG, and 4.17 vs 3.08 for INH, P < .001 for all). The higher the MoM for each analyte the greater the likelihood of preeclampsia.CONCLUSION:
Elevated AFP, hCG, and INH levels >2 MoM are associated with developing early preeclampsia, and the more elevated they are, the higher the likelihood.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Segundo Trimestre da Gravidez
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Alfa-Fetoproteínas
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Gonadotropina Coriônica
/
Inibinas
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article