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Chemical proteomics reveals heat shock protein 60 to be the main cellular target of the marine bioactive sesterterpene suvanine.
Cassiano, Chiara; Monti, Maria Chiara; Festa, Carmen; Zampella, Angela; Riccio, Raffaele; Casapullo, Agostino.
Afiliação
  • Cassiano C; Dipartimento di Scienze Farmaceutiche e BioMediche, Università degli Studi di Salerno, Via Ponte don Melillo, Fisciano, Salerno, Italy.
Chembiochem ; 13(13): 1953-8, 2012 Sep 03.
Article em En | MEDLINE | ID: mdl-22829539
Marine bioactive compounds are potential drug leads because of their diverse pharmacological effects against human diseases. The identification of their cellular targets is crucial for a rational approach to their application in medicinal chemistry. Thus, we have analyzed the cell interactome of suvanine, a sulfated tricyclic terpenoid of marine origin endowed with an interesting anti-inflammatory activity, by application of a chemical proteomic approach. Heat Shock Protein 60, a chaperone involved in the inflammatory response, is the main cellular target of suvanine, which is also able to interfere with protein chaperone activity, giving evidence for its anti-inflammatory properties.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poríferos / Chaperonina 60 / Sesterterpenos / Anti-Inflamatórios Limite: Animals / Humans Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poríferos / Chaperonina 60 / Sesterterpenos / Anti-Inflamatórios Limite: Animals / Humans Idioma: En Ano de publicação: 2012 Tipo de documento: Article