Molecular targets of FTY720 (fingolimod).
Curr Mol Med
; 12(10): 1207-19, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-22834825
ABSTRACT
FTY720 is a recently approved first line therapy for relapsing forms of multiple sclerosis. In this context, FTY720 is a pro-drug, with its anti-multiple sclerosis, immunosuppressive effects largely elicited following its phosphorylation by sphingosine kinase 2 and subsequent modulation of G protein-coupled sphingosine 1-phosphate (S1P) receptor 1 that induces lymphopenia by altering lymphocyte trafficking. A number of other biological effects of FTY720 have, however, been described, including considerable evidence that this drug also has anti-cancer properties. These other effects of FTY720 are independent of S1P receptors, and appear facilitated by modulation of a range of other recently described protein targets by nonphosphorylated FTY720. Here, we review the direct targets of FTY720 that contribute to its anti-cancer properties. We also discuss other recently described protein effectors that, in combination with S1P receptors, appear to contribute to its immunosuppressive effects.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propilenoglicóis
/
Esfingosina
/
Fosfotransferases (Aceptor do Grupo Álcool)
/
Esclerose Múltipla
/
Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article