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Effects of intermittent theta burst stimulation on cerebral blood flow and cerebral vasomotor reactivity.
Pichiorri, Floriana; Vicenzini, Edoardo; Gilio, Francesca; Giacomelli, Elena; Frasca, Vittorio; Cambieri, Chiara; Ceccanti, Marco; Di Piero, Vittorio; Inghilleri, Maurizio.
Afiliação
  • Pichiorri F; Department of Neurology and Psychiatry, Sapienza University, Viale Dell'Università 30, 00185 Rome, Italy.
J Ultrasound Med ; 31(8): 1159-67, 2012 Aug.
Article em En | MEDLINE | ID: mdl-22837279
OBJECTIVES: To determine whether intermittent theta burst stimulation influences cerebral hemodynamics, we investigated changes induced by intermittent theta burst stimulation on the middle cerebral artery cerebral blood flow velocity and vasomotor reactivity to carbon dioxide (CO(2)) in healthy participants. The middle cerebral artery flow velocity and vasomotor reactivity were monitored by continuous transcranial Doppler sonography. Changes in cortical excitability were tested by transcranial magnetic stimulation. METHODS: In 11 healthy participants, before and immediately after delivering intermittent theta burst stimulation, we tested cortical excitability measured by the resting motor threshold and motor evoked potential amplitude over the stimulated hemisphere and vasomotor reactivity to CO(2) bilaterally. The blood flow velocity was monitored in both middle cerebral arteries throughout the experimental session. In a separate session, we tested the effects of sham stimulation under the same experimental conditions. RESULTS: Whereas the resting motor threshold remained unchanged before and after stimulation, motor evoked potential amplitudes increased significantly (P = .04). During and after stimulation, middle cerebral artery blood flow velocities also remained bilaterally unchanged, whereas vasomotor reactivity to CO(2) increased bilaterally (P = .04). The sham stimulation left all variables unchanged. CONCLUSIONS: The expected intermittent theta burst stimulation-induced changes in cortical excitability were not accompanied by changes in cerebral blood flow velocities; however, the bilateral increased vasomotor reactivity suggests that intermittent theta burst stimulation influences the cerebral microcirculation, possibly involving subcortical structures. These findings provide useful information on hemodynamic phenomena accompanying intermittent theta burst stimulation, which should be considered in research aimed at developing this noninvasive, low-intensity stimulation technique for safe therapeutic applications.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Velocidade do Fluxo Sanguíneo / Ultrassonografia Doppler Transcraniana / Artéria Cerebral Média / Estimulação Magnética Transcraniana Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2012 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Velocidade do Fluxo Sanguíneo / Ultrassonografia Doppler Transcraniana / Artéria Cerebral Média / Estimulação Magnética Transcraniana Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2012 Tipo de documento: Article