Unveiling case-control relationships in designing a simple and powerful method for detecting gene-gene interactions.
Genet Epidemiol
; 36(7): 710-6, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-22886951
ABSTRACT
The detection of gene-gene interactions (i.e., epistasis) in the human genome is becoming decisive for the complete characterization of the genetic factors associated with complex binary traits. Despite the fact that many methods have been developed to address this challenging issue, their performance still remains insufficient. We will show how case and control groups store complementary information regarding interactions, and the use of this fundamental property in the design of a new, rapid, and highly powerful epistasis analysis method. Unlike previous approaches where statistical methods are tested over a very limited range of situations, we have performed an exhaustive evaluation of the power of our new method. To this end, we also propose a more comprehensive interpretation of epistasis in which genotype interactions may be of risk, protective, or neutral. In this extended view of genetic interactions, we demonstrate that our method has superior performance than existing approaches, thus, providing a highly powerful tool for the identification of gene-gene interactions associated with binary traits.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estudos de Casos e Controles
/
Interpretação Estatística de Dados
/
Epistasia Genética
/
Modelos Genéticos
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article