An evaluation of reproductive and developmental toxicity of sitaxentan (thelin) in rats.
Birth Defects Res B Dev Reprod Toxicol
; 95(5): 327-36, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22890981
ABSTRACT
Sitaxentan sodium (Thelin) is a once daily, orally bioavailable, highly selective endothelin A receptor antagonist. Initially approved for the treatment of pulmonary arterial hypertension, sitaxentan was withdrawn in 2010 following the recognition of a pattern of idiosyncratic liver injury. During development of this drug, a series of nonclinical studies investigated the effects of orally administered sitaxentan on fertility, embryofetal development, and pre- and postnatal development in the rat; results of these studies are reported here. In the fertility study, sitaxentan did not affect mating behavior, fertility, sperm morphology, or estrous cycle. Sitaxentan was teratogenic in the embyrofetal development study, which was expected based on its pharmacologic mechanism of action. Teratogenic effects included malformations of the head, mouth, face, and large blood vessels. In the pre- and postnatal study, sitaxentan administration was associated with reduced pup survival, large or abnormally shaped livers, and delays in markers of auditory and sexual development. Sitaxentan was detected in plasma of suckling pups receiving milk from females dosed with sitaxentan. These nonclinical study findings were reflected in the sitaxentan product label warnings.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reprodução
/
Tiofenos
/
Testes de Toxicidade
/
Desenvolvimento Embrionário
/
Isoxazóis
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
Limite:
Animals
/
Pregnancy
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article