Discovery of severe fever with thrombocytopenia syndrome bunyavirus strains originating from intragenic recombination.
J Virol
; 86(22): 12426-30, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-22933273
ABSTRACT
This study analyzes available severe fever with thrombocytopenia syndrome virus (SFTSV) genomes and reports that a sublineage of lineage I bears a unique M segment recombined from two of three prevailing SFTSV lineages. Through recombination, the sublineage has acquired nearly complete G1 associated with protective epitopes from lineage III, suggesting that this recombination has the capacity to induce antigenic shift of the virus. Therefore, this study provides some valuable implications for the vaccine design of SFTSV.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trombocitopenia
/
Orthobunyavirus
/
Infecções por Bunyaviridae
/
Febre
Tipo de estudo:
Prognostic_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article