Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.
Bioorg Med Chem Lett
; 22(19): 6181-4, 2012 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-22939233
ABSTRACT
We describe the design, synthesis, and evaluation of benzimidazoles as benzamide replacements within a series of trisubstituted cyclohexane CCR2 antagonists. 7-Trifluoromethylbenzimidazoles displayed potent binding and functional antagonism of CCR2 while being selective over CCR3. These benzimidazoles were also incorporated into lactam-containing antagonists, thus completely eliminating the customary bis-amide.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzimidazóis
/
Cicloexanos
/
Receptores CCR2
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article