Constitutive &#945;- and ß-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines.

Colombo, Alessio; Wang, Huanhuan; Kuhn, Peer-Hendrik; Page, Richard; Kremmer, Elisabeth; Dempsey, Peter J; Crawford, Howard C; Lichtenthaler, Stefan F

Constitutive α- and ß-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines.

Colombo, Alessio; Wang, Huanhuan; Kuhn, Peer-Hendrik; Page, Richard; Kremmer, Elisabeth; Dempsey, Peter J; Crawford, Howard C; Lichtenthaler, Stefan F.

Afiliação

Colombo A; German Center for Neurodegenerative Diseases (DZNE), site Munich, Germany; Adolf Butenandt Institute, LMU Munich, Munich, Germany.
Wang H; Adolf Butenandt Institute, LMU Munich, Munich, Germany.
Kuhn PH; German Center for Neurodegenerative Diseases (DZNE), site Munich, Germany; Adolf Butenandt Institute, LMU Munich, Munich, Germany.
Page R; German Center for Neurodegenerative Diseases (DZNE), site Munich, Germany; Adolf Butenandt Institute, LMU Munich, Munich, Germany.
Kremmer E; Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Molecular Immunology, Munich, Germany.
Dempsey PJ; Department of Pediatrics & Communicable Diseases, The University of Michigan, Ann Arbor, MI, USA.
Crawford HC; Department of Cancer Biology, Mayo Clinic Florida, Jacksonville, FL, USA.
Lichtenthaler SF; German Center for Neurodegenerative Diseases (DZNE), site Munich, Germany; Adolf Butenandt Institute, LMU Munich, Munich, Germany; Technical University Munich, Munich, Germany. Electronic address: stefan.lichtenthaler@dzne.de.

Neurobiol Dis ; 49: 137-47, 2013 Jan.

Article em En | MEDLINE | ID: mdl-22940630

Assuntos

Secretases da Proteína Precursora do Amiloide/metabolismo; Precursor de Proteína beta-Amiloide/metabolismo; Neurônios/enzimologia; Proteínas ADAM/antagonistas & inibidores; Proteínas ADAM/genética; Proteínas ADAM/metabolismo; Proteína ADAM10; Secretases da Proteína Precursora do Amiloide/antagonistas & inibidores; Secretases da Proteína Precursora do Amiloide/genética; Animais; Ácido Aspártico Endopeptidases/antagonistas & inibidores; Ácido Aspártico Endopeptidases/genética; Ácido Aspártico Endopeptidases/metabolismo; Linhagem Celular Tumoral; Células Cultivadas; Córtex Cerebral/efeitos dos fármacos; Córtex Cerebral/enzimologia; Técnicas de Silenciamento de Genes; Células HEK293; Humanos; Proteínas de Membrana/antagonistas & inibidores; Proteínas de Membrana/genética; Proteínas de Membrana/metabolismo; Camundongos Knockout; Neurônios/efeitos dos fármacos; Inibidores de Proteases/farmacologia

Palavras-chave

Alpha-secretase; Alzheimer's disease; Amyloid precursor protein; Beta-secretase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Precursor de Proteína beta-Amiloide / Secretases da Proteína Precursora do Amiloide / Neurônios Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

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