Friction-mediated dynamic disordering of phospholipid membrane by mechanical motions of photoresponsive molecular glue: activation of ion permeation.
J Am Chem Soc
; 134(37): 15273-6, 2012 Sep 19.
Article
em En
| MEDLINE
| ID: mdl-22950752
ABSTRACT
A water-soluble photoresponsive molecular glue, Azo-(18)Glue, consisting of a photochromic azobenzene core and two adhesive dendritic wedges with a total of 18 peripheral guanidinium ion (Gu(+)) pendants tightly adheres to the surface of a phospholipid membrane, even in buffer, via a multivalent salt-bridge formation with phosphate anions. A photomechanical motion of adhering Azo-(18)Glue possibly gives rise to dynamic structural disordering of the phospholipid membrane and activates transmembrane ion permeation. In sharp contrast, no activation of ion permeation results when poorly adhesive Azo-(6)Glue carrying only six Gu(+) pendants is used in place of Azo-(18)Glue.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfolipídeos
/
Fricção
/
Processos Fotoquímicos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article