Longitudinal effect of topical antiglaucoma medications on central corneal thickness.
Clin Exp Ophthalmol
; 41(4): 348-54, 2013.
Article
em En
| MEDLINE
| ID: mdl-22958109
ABSTRACT
BACKGROUND:
To determine the change in central corneal thickness over time and whether the use of long-term topical antiglaucoma medications influences central corneal thickness.DESIGN:
Case control study with retrospective and prospective data collection.PARTICIPANTS:
One hundred eighty-seven eyes of 187 glaucoma patients (mean follow up 6.92 ± 1.67 years) being treated with topical antiglaucoma medications (at least 3 years) with no history of surgery or laser were included and compared with 100 eyes of 100 age-matched, untreated control subjects (mean follow up 6.58 ± 1.93 years) who were glaucoma suspects with normal intraocular pressure not on any treatment.METHODS:
Demographic data, central corneal thickness and intraocular pressure were collected at initial glaucoma diagnosis and at most recent visit, and findings were compared between two groups. MAIN OUTCOMEMEASURES:
Mean change in central corneal thickness in microns (µm).RESULTS:
Central corneal thickness fell significantly (P < 0.0001) in treated eyes but not in control eyes (P = 0.18); mean central corneal thickness reduction was 12.29 ± 13.65 µm in treated eyes and 1.17 ± 8.75 µm in controls. Among treated eyes, central corneal thickness reduction was significant (P < 0.0001) in those treated with either prostaglandins or a combination of prostaglandin and beta-blockers, while no significant reduction occurred in eyes treated with only beta-blockers (P = 0.15) when compared with control eyes.CONCLUSIONS:
Prostaglandins appear to be associated with a small but significant central corneal thickness reduction over time. Serial central corneal thickness measurements might be helpful in glaucoma patients, particularly those on prostaglandins.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prostaglandinas Sintéticas
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Glaucoma de Ângulo Aberto
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Antagonistas Adrenérgicos beta
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Córnea
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Glaucoma de Baixa Tensão
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Anti-Hipertensivos
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article