Structure of hepatitis C virus envelope glycoprotein E2 antigenic site 412 to 423 in complex with antibody AP33.
J Virol
; 86(23): 13085-8, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-22973046
ABSTRACT
We have determined the crystal structure of the broadly neutralizing antibody (bnAb) AP33, bound to a peptide corresponding to hepatitis C virus (HCV) E2 envelope glycoprotein antigenic site 412 to 423. Comparison with bnAb HCV1 bound to the same epitope reveals a different angle of approach to the antigen by bnAb AP33 and slight variation in its ß-hairpin conformation of the epitope. These structures establish two different modes of binding to E2 that antibodies adopt to neutralize diverse HCV.
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Coleções:
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Base de dados:
MEDLINE
Assunto principal:
Conformação Proteica
/
Modelos Moleculares
/
Proteínas do Envelope Viral
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Hepacivirus
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Anticorpos Neutralizantes
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article