[Effect of nebulised iloprost combined with inhaled nitric oxide and oral sildenafil on lung transplant patients. Therapeutic efficacy in pulmonary hypertension during surgery]. / Efecto de iloprost nebulizado combinado con óxido nítrico inhalado y sildenafilo oral en las presiones pulmonares de pacientes sometidos a trasplante pulmonar. Eficacia terapéutica en la hipertensión pulmonar intraoperatoria.
Rev Esp Anestesiol Reanim
; 59(3): 142-9, 2012 Mar.
Article
em Es
| MEDLINE
| ID: mdl-22985755
ABSTRACT
OBJECTIVES:
There is a high incidence of pulmonary hypertension during the lung transplant peri-operative period, and could lead to a haemodynamic deterioration that may require the need of extracorporeal circulation. Our aim was to study the haemodynamic effects on the pulmonary and systemic circulation of the combination of inhaled nitric oxide and iloprost and oral sildenafil in patients with severe pulmonary hypertension during lung transplant surgery. PATIENTS ANDMETHODS:
Seventeen patients received 10µg of nebulised iloprost during the peri-operative period of the lung transplant when their mean pulmonary pressure exceeded 50mmHg. AU the patients received 50mg of oral sildenafil 30min before anaesthetic induction, 20ppm of inhaled nitric oxide after tracheal intubation. The haemodynamic and respiratory variables were recorded at baseline (after anaesthetic induction), prior to the administering of iloprost, and at 5 and 30min after it was given.RESULTS:
The administering of iloprost significantly reduced the pulmonary arterial pressure and significantly increases the cardiac Índex and the right ventrícular ejection fractíon. There were no signíficant changes occurred in the systemic arterial pressure.CONCLUSIONS:
The triple combination significantly reduces the pulmonary pressures in the lung transplant peri-operative and should be considered when there is severe pulmonary hypertension during the surgery or during the immediate post-operative period of lung transplantation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Sulfonas
/
Vasodilatadores
/
Iloprosta
/
Transplante de Pulmão
/
Hipertensão Pulmonar
/
Complicações Intraoperatórias
/
Óxido Nítrico
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Es
Ano de publicação:
2012
Tipo de documento:
Article