Stochastic-shielding approximation of Markov chains and its application to efficiently simulate random ion-channel gating.
Phys Rev Lett
; 109(11): 118101, 2012 Sep 14.
Article
em En
| MEDLINE
| ID: mdl-23005678
ABSTRACT
Markov chains provide realistic models of numerous stochastic processes in nature. We demonstrate that in any Markov chain, the change in occupation number in state A is correlated to the change in occupation number in state B if and only if A and B are directly connected. This implies that if we are only interested in state A, fluctuations in B may be replaced with their mean if state B is not directly connected to A, which shortens computing time considerably. We show the accuracy and efficacy of our approximation theoretically and in simulations of stochastic ion-channel gating in neurons.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativação do Canal Iônico
/
Cadeias de Markov
/
Modelos Teóricos
Tipo de estudo:
Clinical_trials
/
Health_economic_evaluation
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article