The Inactivation of intrinsic antibiotic resistance determinants widens the mutant selection window for quinolones in Stenotrophomonas maltophilia.
Antimicrob Agents Chemother
; 56(12): 6397-9, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-23006759
ABSTRACT
We have determined that the mutational inactivation of the SmeDEF efflux pump and the SmQnr quinolone resistance protein widens the mutant selection windows for ofloxacin and ciprofloxacin of Stenotrophomonas maltophilia by reducing their MICs. Resistant mutants arising from a strain lacking SmeDEF and SmQnr presented levels of susceptibility similar to those of the wild-type strain. This indicates that inactivation of intrinsic resistance determinants might increase the chances for selecting resistant mutants at low antibiotic concentrations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinolonas
/
Stenotrophomonas maltophilia
/
Farmacorresistência Bacteriana
/
Genes Bacterianos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article