Antigen-specific suppression of humoral immunity by anergic Ars/A1 B cells.
J Immunol
; 189(9): 4275-83, 2012 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-23008448
ABSTRACT
Autoreactive anergic B lymphocytes are considered to be dangerous because of their potential for activation and recruitment into autoimmune responses. However, they persist for days and constitute â¼5% of the B cell pool. We assessed their functional potential in the Ars/A1 transgene model, where anergic B cells express a dual-reactive Ag receptor that binds, in addition to a self-Ag, the hapten p-azophenylarsonate (Ars). When Ars/A1 B cells were transferred into adoptive recipients that were immunized with foreign proteins covalently conjugated with Ars, endogenous IgG immune responses to both were selectively and severely diminished, and the development of T helper cells was impaired. Approximately 95% inhibition of the anti-Ars response was attained with â¼4000 transferred Ars/A1 B cells through redundant mechanisms, one of which depended on their expression of MHC class II but not upon secretion of IL-10 or IgM. This Ag-specific suppressive activity implicates the autoreactive anergic B cell as an enforcer of immunological tolerance to self-Ags.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Subpopulações de Linfócitos B
/
Terapia de Imunossupressão
/
Anergia Clonal
/
Epitopos de Linfócito B
/
Formação de Anticorpos
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article