Diastereoselective metal-catalyzed synthesis of C-aryl and C-vinyl glycosides.
Angew Chem Int Ed Engl
; 51(44): 11101-4, 2012 Oct 29.
Article
em En
| MEDLINE
| ID: mdl-23023954
ABSTRACT
Cobalt, the catalyst of choice The diastereoselective cobalt-catalyzed cross-coupling of 1-bromo glycosides and aryl or vinyl Grignard reagents is described. A convenient and inexpensive catalyst, [Co(acac)(3)]/tmeda (acac = acetylacetonate, tmeda = N,N'-tetramethylethylenediamine), gives full αâ
selectivity in the mannose and galactose series, and an αâ
selectivity in the glucose series with α/ßâ
ratios of 1.31-31.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Cobalto
/
Glicosídeos
/
Ferro
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article