JBIR-129 and -139, cytotoxic 34-membered polyol macrolides of microbial origin.
J Nat Prod
; 75(10): 1814-8, 2012 Oct 26.
Article
em En
| MEDLINE
| ID: mdl-23039861
ABSTRACT
New 34-membered polyol macrolides JBIR-129 (1) and JBIR-139 (2) were isolated from the culture of the terrestrial Streptomyces RK74. The planar structures of 1 and 2 were established on the basis of 1D and 2D NMR, ESI-TOF-MS, IR, and UV spectra. The relative configurations of the sugar units were determined by analyzing vicinal ¹H-¹H coupling constants and steric information. Both 1 and 2 showed cytotoxic activity against human ovarian adenocarcinoma SKOV-3 cells with IC50 values of 0.3 and 0.4 µM, respectively.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Macrolídeos
/
Antineoplásicos
Limite:
Female
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Humans
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article