The effect of vitamin E or vitamin A on the prevention of renal scarring in children with acute pyelonephritis.
Pediatr Nephrol
; 28(2): 277-83, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-23052650
ABSTRACT
BACKGROUND:
Numerous factors may contribute to renal tissue injury after urinary tract infection. We have evaluated the effects of vitamins A or E supplementation in combination with antibiotics for the prevention of renal scarring in acute pyelonephritis.METHODS:
A simple non-blind randomized clinical trial was conducted on 61 children aged 1 month to 10 years between 2004 and 2006. The inclusion criteria were positive urine culture, clinical findings, and 99mTc-dimercaptosuccinic acid (DMSA) scintigraphy-based evidence in favor of acute pyelonephritis. The children were randomized into three treatment groups 10-day treatment with only antibiotics (control group; n = 25) and 10-day treatment with supplements of vitamin A (n = 17) or vitamin E (n = 18) in addition to antibiotics during the acute phase of infection. The final analysis was performed after excluding male patients. Each patient was evaluated twice by 99mTc-DMSA scintigraphy performed at least 6 months apart. P < 0.05 was considered to be statistically significant.RESULTS:
The analysis included 108 kidney units. The frequency of inflammation at the beginning of therapy was not significantly different in the three groups (63.3 % in vitamin A, 61 % in vitamin E, and 76.2 % in the control group). A worsening of lesions, based on the second 99mTc-DMSA scan, was observed in 42.5, 0, and 23.3 % of the control, vitamin E, and vitamin A patients, respectively (LR = 26.3, P < 0.001).CONCLUSION:
Vitamins A or E supplements were effective in reducing renal scarring secondary to acute pyelonephritis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pielonefrite
/
Vitamina A
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Vitamina E
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Cicatriz
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Suplementos Nutricionais
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Antioxidantes
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Newborn
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article