Reprint of BMCL_19101.
Bioorg Med Chem Lett
; 22(22): 6821-4, 2012 11 15.
Article
em En
| MEDLINE
| ID: mdl-23083981
The pathogenesis of rheumatoid arthritis is mainly driven by NF-κB-mediated production of cytokines, such as TNF-α. We report herein that the orally available imidazoline-based NF-κB inhibitor, TCH-013, was found to significantly reduce TNF-α signaling and attenuate collagen antibody induced arthritis in BALB/c mice.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Fator de Necrose Tumoral alfa
/
Imidazóis
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article