Synthesis of isoindole and benzoisoindole derivatives of teicoplanin pseudoaglycon with remarkable antibacterial and antiviral activities.
Bioorg Med Chem Lett
; 22(23): 7092-6, 2012 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-23099097
ABSTRACT
The primary amino function of teicoplanin pseudoaglycon has been transformed into arylthioisoindole or benzoisoindole and glycosylthioisoindole derivatives, in a reaction with o-phthalaldehyde or naphtalene-2,3-dicarbaldehyde and various thiols. All of the obtained semisynthetic antibiotics exhibited potent antibacterial activities against Gram-positive bacteria in the ng per ml concentration range. A few of them showed antiviral activity, in particular against influenza virus.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Teicoplanina
/
Isoindóis
/
Antibacterianos
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article