Synthesis of novel ÐТ3 receptor ligands via an unusual Knoevenagel condensation.
Bioorg Med Chem Lett
; 22(24): 7578-81, 2012 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-23131339
ABSTRACT
New 5-acetamido-substituted melatonin derivatives were efficiently synthesized in excellent yields via Knoevenagel condensation. The relative binding affinity of new synthesized compounds to MT3 receptor was tested via enzymatic assays and the X-ray structures of the most potent compounds were determined in complex with MT3.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Melatonina
/
Acetamidas
/
Melatonina
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article