Anti-infective and herbicidal activity of N-substituted 2-aminobenzothiazoles.
Bioorg Med Chem
; 20(24): 7059-68, 2012 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-23140987
ABSTRACT
In this study, a series of N-substituted 2-aminobenzothiazoles was prepared according to a recently developed method. Twelve compounds were tested for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the discussed compounds was also performed against fungal, bacterial and mycobacterial species. The biological activities of some compounds were comparable or higher than the standards phenoxymethylpenicillin or pyrazinamide. The most effective compounds demonstrated insignificant toxicity against the human monocytic leukemia THP-1 cell line. For all compounds, the structure-activity relationships are discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzotiazóis
/
Herbicidas
/
Anti-Infecciosos
/
Antifúngicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article