Analyzing caspase-1 activation during Legionella pneumophila infection in macrophages.
Methods Mol Biol
; 954: 479-91, 2013.
Article
em En
| MEDLINE
| ID: mdl-23150415
ABSTRACT
Caspase-1 is a critical factor in the innate immune response to Legionella pneumophila. The development of methods for analyzing caspase-1 activation pathways and downstream caspase-1-associated activities has helped in understanding the regulation of this protease and the signaling components involved. Here we outline methods for directly detecting active caspase-1, measuring caspase-1 activities and analyzing components involved in the regulation of caspase-1 during L. pneumophila infection in macrophages.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Legionella pneumophila
/
Caspase 1
/
Macrófagos
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article