Functional diffusion-weighted magnetic resonance spectroscopy of the human primary visual cortex at 7 T.
Magn Reson Med
; 69(2): 303-9, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-23165888
ABSTRACT
PURPOSE:
Microstructural and metabolic changes directly related to neuronal activation have been investigated using functional diffusion-weighted spectroscopy.METHODS:
The volume of interest was positioned in the primary visual cortex. A time series of alternating diffusion- and non-diffusion-weighted (1)H spectra was acquired at 7 T employing stimulated echo acquisition mode sequence and a long diffusion time (Δ = 245 ms). Time-resolved series of metabolite apparent diffusion coefficient values were derived.RESULTS:
Significant increases in apparent diffusion coefficient of 3.3 ± 1.4% (p = 0.05) and 3.9 ± 0.9% (p = 0.002) for total n-acetyl aspartate and total creatine, respectively, and 8.1 ± 2.5% (p = 0.03) for total choline were observed in response to visual stimulation.CONCLUSION:
The increase in apparent diffusion coefficient for these metabolites is a potential indication for microstructural changes in neurons during neural activation and/or for an increase in the energy-dependent cytoplasmic streaming associated with enhanced metabolism during visual stimulation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Visual
/
Percepção Visual
/
Espectroscopia de Ressonância Magnética
/
Colina
/
Ácido Aspártico
/
Creatina
/
Imagem de Difusão por Ressonância Magnética
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article