A natural product inspired hybrid approach towards the synthesis of novel pentamidine based scaffolds as potential anti-parasitic agents.
Bioorg Med Chem Lett
; 23(1): 291-6, 2013 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-23182089
ABSTRACT
A natural product inspired molecular hybridization approach led us to a series of novel pentamidine based pyrimidine and chalcone scaffolds. All the hybrids were evaluated for their anti-leishmanial potential. Most of the screened compounds have showed significant in vitro anti-leishmanial activity with less cytotoxicity in comparison to the standard drugs (pentamidine, sodium stibogluconate, and miltefosine). Additionally, anti-malarial screening of these compounds was also done and four compounds have shown superior activity against chloroquine resistance strain (K1) of Plasmodium falciparum.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pentamidina
/
Produtos Biológicos
/
Antiprotozoários
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article