Lipophilic silver nanoparticles and their polymeric entrapment into targeted-PEG-based micelles for the treatment of glioblastoma.
Adv Healthc Mater
; 1(3): 342-7, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-23184752
ABSTRACT
A simple method for the synthesis of lipophilic Ag NPs have been developed. The coated Ag NPs have been entrapped into a FDA-approved and targetable PEG-based polymeric nanoparticles, and this nanocarrier has been conjugated with the peptide chlorotoxin. Uptake experiments have shown a cell-specific recognition of the Ag-1-PNPs-Cltx on U87MG cell lines in comparison to Balb/3T3. The uptake of Ag into the cells was quantified and an interesting cytotoxic effect (IC50 = 45 µM) has been found on glioblastoma cell lines.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polietilenoglicóis
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Prata
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Portadores de Fármacos
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Glioblastoma
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Nanocápsulas
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Nanopartículas Metálicas
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article