Supramolecular hydrogels with reverse thermal gelation properties from (oligo)tyrosine containing block copolymers.
Biomacromolecules
; 14(1): 200-6, 2013 Jan 14.
Article
em En
| MEDLINE
| ID: mdl-23190093
ABSTRACT
Novel block copolymers comprising poly(ethylene glycol) (PEG) and an oligo(tyrosine) block were synthesized in different compositions by N-carboxyanhydride (NCA) polymerization. It was shown that PEG2000-Tyr(6) undergoes thermoresponsive hydrogelation at a low concentration range of 0.25-3.0 wt % within a temperature range of 25-50 °C. Cryogenic transmission electron microscopy (Cryo-TEM) revealed a continuous network of fibers throughout the hydrogel sample, even at concentrations as low as 0.25 wt %. Circular dichroism (CD) results suggest that better packing of the ß-sheet tyrosine block at increasing temperature induces the reverse thermogelation. A preliminary assessment of the potential of the hydrogel for in vitro application confirmed the hydrogel is not cytotoxic, is biodegradable, and produced a sustained release of a small-molecule drug.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
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Polietilenoglicóis
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Polímeros
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Tirosina
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Hidrogéis
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Temperatura Alta
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article