Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes.
Org Biomol Chem
; 11(13): 2116-39, 2013 Apr 07.
Article
em En
| MEDLINE
| ID: mdl-23196931
ABSTRACT
An efficient procedure for the concise synthesis of hetero-bis-metallated alkenes as useful building blocks for the modular access to highly elaborate polyenes and stabilized analogues is reported. By applying these bifunctional olefins in convergent Stille/Suzuki-Miyaura couplings, novel, carefully selected side chain analogues of the potent RNA polymerase inhibitor etnangien were synthesized by a modular late stage coupling strategy and evaluated for antibacterial and antiproliferative activities.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Polienos
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Bacillus subtilis
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Macrolídeos
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Corynebacterium
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Alcenos
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Antibacterianos
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article